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1

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

Lovering, Frank, Bikker, Jack, Humblet, Christine

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.11 MB

english, 2009

2

ChemInform Abstract: Design and Biological Evaluation of Non-Peptide Analogues of Omega-Conotoxin MVIIA.

Stefan Menzler, Jack A. Bikker, Nirmala Suman-Chauhan, David C. Horwell

Journal:

Year:

2000

File:

PDF, 33 KB

2000

3

ChemInform Abstract: Kinase Domain Mutations in Cancer: Implications for Small Molecule Drug Design Strategies

Jack A. Bikker, Natasja Brooijmans, Allan Wissner, Tarek S. Mansour

Journal:

Year:

2009

File:

PDF, 15 KB

2009

4

Synthesis and pharmacological evaluation of aminopyrimidine series of 5-HT1A partial agonists

Amy B. Dounay, Nancy S. Barta, Jack A. Bikker, Susan A. Borosky, Brian M. Campbell, Terry Crawford, Lynne Denny, Lori M. Evans, David L. Gray, Pil Lee, Edward A. Lenoir, Wenjian Xu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.35 MB

english, 2009

5

Synthesis of a non-peptide analogue of omega-conotoxin MVIIA

Stefan Menzler, Jack A Bikker, David C Horwell

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 219 KB

english, 1998

6

Design and biological evaluation of non-peptide analogues of omega-conotoxin MVIIA

Stefan Menzler, Jack A Bikker, Nirmala Suman-Chauhan, David C Horwell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 238 KB

english, 2000

7

Development of QSAR models for microsomal stability: identification of good and bad structural features for rat, human and mouse microsomal stability

Yongbo Hu, Ray Unwalla, R. Aldrin Denny, Jack Bikker, Li Di, Christine Humblet

Journal:

Journal of Computer-Aided Molecular Design

Year:

2010

Language:

english

File:

PDF, 567 KB

english, 2010

8

Kinase Domain Mutations in Cancer: Implications for Small Molecule Drug Design Strategies

Bikker, Jack A., Brooijmans, Natasja, Wissner, Allan, Mansour, Tarek S.

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 2.12 MB

english, 2009

9

Theoretical studies applicable to the design of novel anticonvulsants: Part 2. A comparison of AM1, MNDO, and PM3 semiempirical molecular orbital conformational analyses of dihydropyridine calcium channel blockers

Jack Andrew Bikker, Donald Fredric Weaver

Journal:

Journal of Molecular Structure: THEOCHEM

Year:

1993

Language:

english

File:

PDF, 1.12 MB

english, 1993

10

A structural informatics approach to mine kinase knowledge bases

Natasja Brooijmans, Dominick Mobilio, Gary Walker, Ramaswamy Nilakantan, Rajiah A. Denny, Eric Feyfant, David Diller, Jack Bikker, Christine Humblet

Journal:

Drug Discovery Today

Year:

2010

Language:

english

File:

PDF, 810 KB

english, 2010

11

Quantum Pharmacologic Studies Applicable to the Design of Anticonvulsants: Theoretical Conformational Analysis and Structure-Activity Studies of Barbiturates

Jack Andrew Bikker, Julia Kubanek, Donald F. Weaver

Journal:

Year:

1994

Language:

english

File:

PDF, 2.33 MB

english, 1994

12

Direct Oxa-Pictet−Spengler Cyclization to the Natural (3a,5)- trans -Stereochemistry in the Syntheses of (+)-7-Deoxyfrenolicin B and (+)-7-Deoxykalafungin

Eid, Clark N., Shim, Jaechul, Bikker, Jack, Lin, Melissa

Journal:

Journal of Organic Chemistry

Year:

2009

Language:

english

File:

PDF, 319 KB

english, 2009

13

G-Protein Coupled Receptors: Models, Mutagenesis, and Drug Design

Bikker, Jack Andrew, Trumpp-Kallmeyer, Susanne, Humblet, Christine

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 299 KB

english, 1998

14

Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ

Pellicciari, Roberto, Camaioni, Emidio, Gilbert, Adam M., Macchiarulo, Antonio, Bikker, Jack A., Shah, Falgun, Bard, Joel, Costantino, Gabriele, Gioiello, Antimo, Robertson, Graeme M., Sabbatini, Paol

Journal:

Year:

2011

Language:

english

File:

PDF, 486 KB

english, 2011

15

Theoretical studies applicable to the design of novel anticonvulsants: an AM1 molecular orbital structure–activity study of dihydropyridine calcium channel antagonists

Bikker, Jack Andrew, Weaver, Donald Fredric

Journal:

Canadian Journal of Chemistry

Year:

1992

Language:

english

File:

PDF, 804 KB

english, 1992

16

Advances in the development of novel aggrecanase inhibitors

Gilbert, Adam M, Bikker, Jack A, O'Neil, Steven V

Journal:

Expert Opinion on Therapeutic Patents

Year:

2011

Language:

english

File:

PDF, 780 KB

english, 2011

17

PF-06804103, a site-specific anti-HER2 antibody-drug conjugate for the treatment of HER2-expressing breast, gastric, and lung cancers

Graziani, Edmund I., Sung, Matthew, Ma, Dangshe, Narayanan, Bitha, Marquette, Kimberly, Puthenveetil, Sujiet, Tumey, L. Nathan, Bikker, Jack, Casavant, Jeffrey, Bennett, Eric M, Charati, Manoj B, Gola

Journal:

Molecular Cancer Therapeutics

Year:

2020

File:

PDF, 3.00 MB

2020

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